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        neXtProt
        SIB - Swiss Institute of Bioinformatics
        Geneva, Switzerland
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Description: Controlled vocabulary of metal-binding sites
File name:   cv_metal.txt
Last update: 05-May-2021

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 The definition of the CV is provided in the following format:

 ---------  ---------------------------     ----------------------
 Line code  Content                         Occurrence in an entry
 ---------  ---------------------------     ----------------------
 ID         Identifier (metal name)         Once; starts an entry
 AC         Accession (CVME_xxxx)           Once
 DE         Definition                      Once or more
 SY         Synonyms                        Optional; once or more
 KW         X-ref to Swiss-Prot keyword     Optional; once or more
 //         Terminator                      Once; ends an entry

AN   Next free AC: CVME_0046
__________________________________________________________________________
ID   Calcium.
AC   CVME_0001
DE   Annotate an amino acid residue that binds a calcium (Ca(2+)) cation.
DE   Calcium is an alkaline earth metal with the atomic number: 20.
SY   Ca; Calcium ion; Ca ion.
KW   KW-0106:Calcium.
//
ID   Calcium or magnesium.
AC   CVME_0037
DE   Annotate an amino acid residue that binds either a calcium (Ca(2+))
DE   or a magnesium (Mg(+2)) cation.
SY   Calcium 6 or magnesium; Calcium 5 or magnesium; Calcium 4 or magnesium.
KW   KW-0106:Calcium.
KW   KW-0460:Magnesium.
//
ID   Cobalt.
AC   CVME_0002
DE   Annotate an amino acid residue that binds a cobalt (Co(2+) or Co(3+))
DE   cation. Cobalt is a metal with the atomic number: 27.
SY   Co; Cobalt ion; Co ion; Cobalt cation; Co cation.
KW   KW-0170:Cobalt.
//
ID   Cobalt (cobalamin axial ligand).
AC   CVME_0003
DE   Annotate an amino acid residue that binds a cobalt (Co(3+)) cation
DE   that is in the center of the tetrapyrrole ring structure (corrin ring)
DE   of a cobalamin cofactor.
KW   KW-0846:Cobalamin.
KW   KW-0170:Cobalt.
//
ID   Cobalt (cobalamin 2 axial ligand).
AC   CVME_0038
DE   Annotate an amino acid residue that binds a cobalt (Co(3+)) cation
DE   that is in the center of the tetrapyrrole ring structure (corrin ring)
DE   of a cobalamin cofactor.
SY   Cobalt (Cob(II)alamin axial ligand).
KW   KW-0846:Cobalamin.
KW   KW-0170:Cobalt.
//
ID   Cobalt (methylcob(III)alamin axial ligand).
AC   CVME_0044
DE   Annotate an amino acid residue that binds a cobalt (Co(3+)) cation
DE   that is in the center of the tetrapyrrole ring structure (corrin ring)
DE   of a cobalamin cofactor.
KW   KW-0846:Cobalamin.
KW   KW-0170:Cobalt.
//
ID   Copper.
AC   CVME_0004
DE   Annotate an amino acid residue that binds a copper (Cu(2+) or Cu(1+))
DE   cation. Copper is a metal with the atomic number: 29.
SY   Cu; Copper ion; Cu ion; Copper cation; Cu cation; Copper(2+); Copper A1; Copper A2; Cu(2+).
KW   KW-0186:Copper.
//
ID   Copper or nickel.
AC   CVME_0005
DE   Annotate an amino acid residue that binds either a copper (Cu(2+)) or
DE   a nickel (Ni(2+)) cation.
KW   KW-0186:Copper.
KW   KW-0533:Nickel.
//
ID   Copper or zinc.
AC   CVME_0006
DE   Annotate an amino acid residue that binds either a copper (Cu(2+)) or
DE   a zinc (Zn(2+)) cation.
SY   Zinc or copper.
KW   KW-0186:Copper.
KW   KW-0862:Zinc.
//
ID   Divalent metal cation.
AC   CVME_0007
DE   Annotate an amino acid residue that binds an unspecified divalent
DE   metal cation.
//
ID   Iron.
AC   CVME_0008
DE   Annotate an amino acid residue that binds an iron (Fe(2+) or Fe(3+))
DE   cation. Iron is a metal with the atomic number: 26.
SY   Iron ion; Iron cation; Fe(3+); Fe; Fe ion; Fe cation.
KW   KW-0408:Iron.
//
ID   Iron (heme 1 axial ligand).
AC   CVME_0009
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme 2 axial ligand).
AC   CVME_0010
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme A axial ligand).
AC   CVME_0011
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
SY   Iron (low-spin heme A axial ligand); Iron (high-spin heme A3 axial ligand).
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme A3 axial ligand).
AC   CVME_0012
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme axial ligand).
AC   CVME_0013
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme distal ligand).
AC   CVME_0014
DE   Annotate an amino acid residue that binds distally an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme proximal ligand).
AC   CVME_0015
DE   Annotate an amino acid residue that binds proximally an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme B axial ligand).
AC   CVME_0036
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme b562 axial ligand).
AC   CVME_0016
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme b566 axial ligand).
AC   CVME_0017
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme b 1 axial ligand).
AC   CVME_0043
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron (heme b 2 axial ligand).
AC   CVME_0045
DE   Annotate an amino acid residue that binds axially an iron (Fe(2+))
DE   cation which is coordinated to the porphyrin group of an heme group.
KW   KW-0349:Heme.
KW   KW-0408:Iron.
//
ID   Iron-sulfur (2Fe-2S).
AC   CVME_0018
DE   Annotate an amino acid residue that binds an iron atom in a 2Fe-2S
DE   iron-sulfur complex which consist of two iron ions bridged by two
DE   sulfide ions and coordinated by four ligands (Cys or His).
KW   KW-0411:Iron-sulfur.
//
ID   Iron-sulfur (3Fe-4S).
AC   CVME_0031
DE   Annotate an amino acid residue that binds an iron atom in a 3Fe-4S
DE   iron-sulfur complex which consist of three iron ions bridged by four
DE   sulfide ions and coordinated by three ligands (Cys or His).
KW   KW-0411:Iron-sulfur.
//
ID   Iron-sulfur (4Fe-4S).
AC   CVME_0019
DE   Annotate an amino acid residue that binds an iron atom in a 4Fe-4S
DE   iron-sulfur complex which consist of four iron ions bridged by four
DE   sulfide ions and coordinated by four ligands (Cys or His).
KW   KW-0411:Iron-sulfur.
//
ID   Iron-sulfur (4Fe-4S-S-AdoMet).
AC   CVME_0020
DE   Annotate an amino acid residue that binds an iron atom in a 4Fe-4S
DE   iron-sulfur complex which consist of four iron ions bridged by four
DE   sulfide ions and coordinated by four ligands (Cys or His).
KW   KW-0411:Iron-sulfur.
//
ID   Iron-sulfur (4Fe-4S-substrate).
AC   CVME_0033
DE   Annotate an amino acid residue that binds an iron atom in a 4Fe-4S
DE   iron-sulfur complex which consist of four iron ions bridged by four
DE   sulfide ions and coordinated by four ligands (Cys or His).
KW   KW-0411:Iron-sulfur.
//
ID   Iron, catalytic.
AC   CVME_0039
DE   Annotate an amino acid residue that binds an iron (Fe(2+) or Fe(3+))
DE   cation. Iron is a metal with the atomic number: 26.
SY   Iron ion; Iron cation; Fe; Fe ion; Fe cation.
KW   KW-0408:Iron.
//
ID   Iron or nickel.
AC   CVME_0034
DE   Annotate an amino acid residue that binds either an iron (Fe(2+) or Fe(3+))
DE   cation or a nickel (Ni(2+)) cation.
KW   KW-0408:Iron.
KW   KW-0533:Nickel.
//
ID   Iron or copper.
AC   CVME_0035
DE   Annotate an amino acid residue that binds either an iron (Fe(2+) or Fe(3+))
DE   cation or a copper (Cu(2+)) cation.
KW   KW-0408:Iron.
KW   KW-0186:Copper.
//
ID   Magnesium.
AC   CVME_0021
DE   Annotate an amino acid residue that binds a magnesium (Mg(+2)) cation.
DE   Magnesium is an alkaline earth metal with the atomic number: 12.
SY   Magnesium ion; Magnesium cation; Mg; Mg ion; Mg cation.
KW   KW-0460:Magnesium.
//
ID   Magnesium or calcium.
AC   CVME_0022
DE   Annotate an amino acid residue that binds either a magnesium (Mg(+2))
DE   or a calcium (Ca(+2)) cation.
KW   KW-0106:Calcium.
KW   KW-0460:Magnesium.
//
ID   Magnesium or manganese.
AC   CVME_0023
DE   Annotate an amino acid residue that binds either a magnesium (Mg(+2))
DE   or a manganese (Mn(+2)) cation.
SY   Magnesium 1 or manganese; Magnesium 2 or manganese.
KW   KW-0460:Magnesium.
KW   KW-0464:Manganese.
//
ID   Manganese.
AC   CVME_0030
DE   Annotate an amino acid residue that binds a manganese (Mn(+2)) cation.
DE   Manganese is a metal with the atomic number: 25.
SY   Manganese ion; Manganese cation; Mn; Mn ion; Mn cation.
KW   KW-0464:Manganese.
//
ID   Manganese or nickel.
AC   CVME_0040
DE   Annotate an amino acid residue that binds either a manganese (Mn(+2))
DE   or a nickel (Ni(2+)) cation.
DE   Manganese is a metal with the atomic number: 25.
DE   Nickel is a metal with the atomic number: 28.
KW   KW-0464:Manganese.
KW   KW-0533:Nickel.
//
ID   Metal cation.
AC   CVME_0041
DE   Annotate an amino acid residue that binds a metal cation.
//
ID   Molybdenum.
AC   CVME_0032
DE   Annotate an amino acid residue that binds a molybdenum atom.
DE   Molybdenum is a metal with the atomic number: 42.
SY   Molybdenum ion; Molybdenum cation; Mo; Mo ion; Mo cation; Molybdenum (Mo-molybdopterin metal ligand).
DR   KW-0500:Molybdenum.
//
ID   Molybdenum-pterin.
AC   CVME_0024
DE   Annotate an amino acid residue that binds a molybdenum atom coordinated
DE   to the sulfur atoms of a pterin derivative (molybdopterin [MPT]).
SY   Molybdopterin.
DR   KW-0500:Molybdenum.
//
ID   Nickel.
AC   CVME_0025
DE   Annotate an amino acid residue that binds a nickel (Ni(2+)) cation.
DE   Nickel is a metal with the atomic number: 28.
SY   Nickel ion; Nickel cation; Ni; Ni ion; Ni cation.
KW   KW-0533:Nickel.
//
ID   Potassium.
AC   CVME_0026
DE   Annotate an amino acid residue that binds a potassium (K(+)) cation.
DE   Potassium is an alkaline earth metal with the atomic number: 19.
SY   Potassium ion; Potassium cation; K; K ion; K cation.
KW   KW-0630:Potassium.
//
ID   Sodium.
AC   CVME_0027
DE   Annotate an amino acid residue that binds a sodium (Na(+)) cation.
DE   Sodium is an alkaline earth metal with the atomic number: 11.
SY   Sodium ion; Sodium cation; Na; Na ion; Na cation.
KW   KW-0915:Sodium.
//
ID   Zinc.
AC   CVME_0028
DE   Annotate an amino acid residue that binds a zinc (Zn(2+)) cation.
DE   Zinc is a metal with the atomic number: 30.
SY   Zinc ion; Zinc cation; Zn; Zn ion; Zn cation; Zn(2+).
KW   KW-0862:Zinc.
//
ID   Zinc or iron.
AC   CVME_0029
DE   Annotate an amino acid residue that binds either a zinc (Zn(2+)) or an
DE   iron (Fe(2+)) cation.
KW   KW-0408:Iron.
KW   KW-0862:Zinc.
//
ID   Zinc or magnesium.
AC   CVME_0042
DE   Annotate an amino acid residue that binds either a zinc (Zn(2+)) or a
DE   magnesium (Mg(2+)) cation.
SY   Zinc 1 or magnesium.
KW   KW-0862:Zinc.
KW   KW-0460:Magnesium.
//